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Lisa Loeb was born in Maryland on March 11, 1968 with three siblings – Benjamin, Phillip and Debbie. She was raised in Texas, where she attended an all-girls school, The Hockaday School. In 1986, upon graduating high school, she attended Brown University and finished a degree in comparative literature on 1990.

During Loeb’s college years, she and Elizabeth Mitchell formed a band called “Liz and Lisa”, featuring their Brown classmate (but soon-to-be singer/songwriter) Duncan Sheik as their guitarist and Rick Lassiter as their bassist. The duo released two independent albums – “Liz and Lisa” and “Liz and Lisa: Days Were Different”. Loeb developed a following from her solo performances on the New York City club circuit, where she sold her songs through “The Purple Tape”.

Lisa Loeb was first discovered by friend Ethan Hawke, whom she met through friends in the NYC theater community. It was Hawke, who gave a tape of Loeb's song "Stay (I Missed You)" to director Ben Stiller and suggested it to be included in the movie Reality Bites. It then went on to be a massive hit on the American music charts. Before the huge success, Loeb already released two albums together with Elizabeth Mitchell and their band Liz and Lisa. She has also worked with upcoming musicians such as Duncan Sheik and Rick Lassiter while she was taking up a degree in Brown University.

Loeb released her debut album Tails, in September 1995. The album achieved platinum status with the carrying the Top-Twenty hit "Do you sleep?” She had her second album entitled Firecracker in 1997. Though it only reached a gold status, it was critically praised and the carrier single "I Do" became a popular radio hit. During this time, Loeb paid more attention to her band, Nine Stories.

In 1998, Loeb guest-starred in television show The Nanny and played a voice in The Rugrats Movie. She also played a reporter in the 1999 horror flick “House on Haunted Hill” and was featured in “Serial Killing 101” on 2004.

Her next project, Cake and Pie, was a commercial failure, despite achieving excellent reviews from critics. Her record label eventually dropped her and she then released albums independently. This nearsighted talented woman is an avid Hello Kitty fan, and has earned a distinction for wearing tortoiseshell glasses.

She had her first reality show with then boyfriend Dweezil Zappa in 2004, entitled Dweezil and Lisa. It was followed her own reality show #1 on E! in 2006 and at the same time, released her latest album, “The Very Best of Lisa Loeb”.