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Katherine Marie Heigl was born in Washington, D.C., in November 24, 1978. She is of German and Irish descent, and was raised under the Church of Jesus Christ of Latter-day Saints. She and her family first lived in Virginia and then in Denver before they settled in New Canaan, Connecticut. When she was nine, her aunt took pictures of her and sent them to modeling agencies, with the permission of her parents. This became the jumpstart of her modeling career, as she posed for Sears and Lord & Taylor catalogs., which was soon was followed by a Cheerios commercial.

Her big-screen debut was a spot in the 1992 movie “That Night”, which starred C. Thomas Howell and Juliette Lewis. Heigl soon appeared in Steven Soderbergh's 1993 drama King of the Hill and in the comedy My Father the Hero in 1994. Since Heigl continued to attend New Canaan High School, she balanced her TV, film and modeling career by accepting gigs only during weekends, vacations and holidays.

In 1995, Heigl starred opposite Steven Seagal in Under Siege 2: Dark Territory. While focusing on her acting career, she continued her modeling stints, as she became a regular in magazines such as Seventeen. Her parents divorced in 1996, and in 1997, she moved to Los Angeles with her mother, who also became her manager at that time.

Heigl became more inclined to the boob tube in 1999, as she was cast for the role of Isabel Evans in the science fiction drama Roswell. She also appeared in three TV movies by 2003, as well as several movies such as 100 Girls (2001) and Valentine, while doing Roswell. In 2005, Heigl took on what would become her most notable role in a television series, as Dr. Isobel "Izzie" Stevens on Grey's Anatomy. She was nominated for a Golden Globe for her work in the said TV drama, and in September 2007, Heigl won an Emmy for Outstanding Supporting Actress in a Drama series, still for her role in the same series.

She also appeared in FHM and Maxim calendars, and in 2006, she was voted #12 on Maxim's Hot 100, and the 19th "Sexiest Woman in the World" by FHM. Heigl has been engaged to singer Josh Kelley in June 2006, and it is said that they will marry on December 23 2007 on a Utah ranch property, where there will be a tribute to Heigl’s late brother Jason before the wedding ceremony.